制药工程

电子邮箱

liuhanghang@ctgu.edu.cn

招收专业

化学；药学

研究方向

纳米酶催化；纳米药物递送；天然产物活性开发；脑疾病诊疗

个人简介

刘航航，女，1992年，博士，校聘副教授。2015年6月于河南师范大学获理学学士学位，2018年6月于苏州大学获理学硕士学位，2022年6月于苏州大学放射医学与辐射防护国家重点实验室获医学博士学位，2022年7月以青年拔尖人才计划引进三峡大学生物与制药学院。主要从事多功能纳米药物的构建、智能靶向型纳米载药系统的设计、天然产物纳米酶的生物医学应用研究，近5年在J. Am. Chem. Soc.、Adv. Mater.、Nano Today、Adv. Funct. Mater.、Anal. Chem.、ACS Appl. Mater. Interfaces、J. Mater. Chem. B等国际知名期刊发表SCI论文30余篇，封面论文2篇。主要讲授课程《物理化学》、《物理化学实验》。

主要学术论文：

1. Hanghang Liu^#; Qing Zheng^#; Jiaxin Yuan; Yifan Gao; Tingting Wang; Hao Zhang; Zhen Li*. Modulating SQSTM1/p62-dependent selective autophagy of neurons by activating Nrf2 with multifunctional nanoparticles to eliminate α-synuclein aggregates and boost therapy of Parkinson’s disease. Nano Today 2023, 49: 101770. (IF=18.962)

2. Hanghang Liu; Menglong Hua; Qing Zheng; Yifan Gao; Zhen Li*. Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles. MedComm – Biomaterials and Applications 2023, 2 (2): e47.

3. Hanghang Liu; Yaobao Han; Tingting Wang; Hao Zhang; Qi Xu; Jiaxin Yuan; Zhen Li*. Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles. Journal of the American Chemical Society 2020, 142 (52): 21730-21742. (IF=16.383，封面)

4. Hanghang Liu; Feng Ren; Xingguo Zhou; Changqiu Ma; Tingting Wang; Hao Zhang; Qiao Sun*; Zhen Li*. Ultra-Sensitive Detection and Inhibition of the Metastasis of Breast Cancer Cells to Adjacent Lymph Nodes and Distant Organs by Using Long-Persistent Luminescence Nanoparticles. Analytical Chemistry 2019, 91 (23): 15064-15072. (IF=8.008，封面)

5. Hanghang Liu; Feng Ren; Hao Zhang; Yaobao Han; Huizhu Qin; Jianfeng Zeng; Yong Wang; Qiao Sun*; Zhen Li*; Mingyuan Gao. Oral administration of highly bright Cr³⁺ doped ZnGa₂O₄ nanocrystals for in vivo targeted imaging of orthotopic breast cancer. Journal of Materials Chemistry B 2018, 6 (10): 1508-1518. (IF=7.571)

6. Hanghang Liu^#; Sepehr Talebian^#; Kara L. Vine; Zhen Li*; Javad Foroughi*. Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy. Nano Select 2022, 3 (1): 212-226.

7. Jiaxin Yuan; Hanghang Liu; Hao Zhang; Tingting Wang; Qing Zheng; Zhen Li*. Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease. Advanced Materials 2022, 34 (11): 2108435. (IF=32.086，封面)

8. Qing Zheng; Hanghang Liu; Hao Zhang; Yaobao Han; Jiaxin Yuan; Tingting Wang; Yifan Gao; Zhen Li*. Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease. Advanced Science 2023, 10 (22): 2300758.

9. Bolin Bao; Hanghang Liu; Yaobao Han; Liyao Xu; Wei Xing*; Zhen Li*. Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury. ACS Applied Materials & Interfaces 2023, 15 (13): 16460-16470.

10. Feng Ren; Hanghang Liu; Hao Zhang; Zhilin Jiang; Bing Xia; Cécile Genevois; Tao He; Mathieu Allix; Qiao Sun; Zhen Li*; Mingyuan Gao. Engineering NIR-IIb fluorescence of Er-based lanthanide nanoparticles for through-skull targeted imaging and imaging-guided surgery of orthotopic glioma. Nano Today 2020, 34: 100905. (IF=18.962)

11. Xingguo Zhou; Hanghang Liu; Yanhui Zheng; Yaobao Han; Tingting Wang; Hao Zhang; Qiao Sun; Zhen Li*. Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor. ACS Applied Materials & Interfaces 2020, 12 (4): 4231-4240. (IF=10.383)

12. Changqiu Ma; Hanghang Liu; Feng Ren; Zheng Liu; Qiao Sun; Chongjun Zhao*; Zhen Li*. The Second Near-Infrared Window Persistent Luminescence for Anti-Counterfeiting Application. Crystal growth & design 2020, 20 (3): 1859-1867. (IF=4.01)

13. Tingting Wang; Hao Zhang; Hanghang Liu; Qiang Yuan; Feng Ren; Yaobao Han; Qiao Sun; Zhen Li*; Mingyuan Gao. Boosting H₂O₂-Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near-Infrared Light Irradiation. Advanced Functional Materials, 2020, 30 (3): 1906128. (IF=19.924，封面)

14. Hao Zhang; Tingting Wang; Hanghang Liu; Yaobao Han; Qing Zheng; Qi Xu; Bolin Bao; Wei Xing*; Zhen Li*. Boost therapy of hepatocellular carcinoma by amplifying vicious cycle between mitochondrial oxidative stress and endoplasmic reticulum stress via biodegradable ultrasmall nanoparticles and old drug. Nano Today, 2022, 46: 101601. (IF=18.962)

15. Qi Xu; Hao Zhang*; Hanghang Liu; Yaobao Han; Weibao Qiu; Zhen Li*. Inhibiting autophagy flux and DNA repair of tumor cells to boost radiotherapy of orthotopic glioblastoma. Biomaterials, 2022, 280: 121287. (IF=15.304)

近五年科研项目

(1) 国家自然科学基金青年科学基金，30万，2025.01-2027-12，主持；

(2) 湖北省自然科学基金（青年项目），8万，2024.03-2026.03，主持；

(3) 放射医学与辐射防护国家重点实验室开放课题，3万，2023.08-2024.12，主持；

(4) 三峡大学高层次人才科研启动及平台建设经费（拔尖人才），70万，2022.08-2025.07，主持。

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