生物科学

电子邮箱

zhouchao@ctgu.edu.cn

招收专业

生物学（学硕）、生物与医药（专硕），计算机科学与技术（学硕）

研究方向

生物信息学，表观遗传学

个人简介

周超，男，博士，教授，博士生导师。湖北省人才工程入选者，湖北省博士服务团成员，湖北省遗传学会副秘书长，湖北省生物信息学会理事，湖北省药理学会中药药理专业委员会委员，中药材信息化育种宜昌市重点实验室负责人。2018年博士毕业于华中农业大学作物遗传改良全国重点实验室，同年受聘于三峡大学全职工作。一直从事植物生物信息学和表观遗传学的研究，相关成果发表SCI论文30余篇，以第一作者或通讯作者在Nature Plants，Nucleic Acids Research，Plant Physiology，Plant communications，Horticulture Research等国内外著名刊物上发表10余篇，其中ESI高被引论文1篇；主持国家自然科学基金2项，湖北省自然科学基金1项，其他厅局级和横向项目10余项，授权国家发明专利3项。目前，担任PLOS ONE等国际期刊编委。主讲《生物大数据》，《生物信息学》等课程。

主要研究论文（^#第一作者，^*通讯作者）

1. Qing Xu^#, Chang Liu^#, Bin Li, Kewei Tian, Lei You, Li Xie, Huang Wang, Meide Zhang, Wuxian Zhou, Yonghong Zhang^*, Chao Zhou^*. A chromosome-scale genome assembly and Epigenomic profiling reveal temperature-dependent histone methylation in iridoid biosynthesis regulation in Scrophularia ningpoensis. Horticulture Research. 2025 Mar 4;12(3): uhae328.

2. Bintao Guo^#, Xinlin Wei^#, Shuangcheng Liu, Wenchao Cui^*, Chao Zhou^*. Deep learning modeling of RNA ac4C deposition reveals the importance of plant alternative splicing Plant Molecular Biology. 2024 Oct 28;114(6):118.

3. Kewei Tian, Chang Liu, Yanjun Cai, and Chao Zhou. Role of 6mA in the regulation of metabolic biosynthesis in Sorghum callus. Journal of Agricultural and Food Chemistry. 2024 Aug 28; 72(34):19232-19245.

4. Chao Zhou, Xinlin Wei, Shuangcheng Liu, Chang Liu, Kexin Tian, Dechun Zhang. Global Characterization of DNA Methylation during Rice Leaf Angle Development. Journal of Agricultural and Food Chemistry. 2024 Aug 28;72(34):19219-19231. 5. Siqi Ma^#, Hanlin Zhou^#, Tingting Ren, Er‑ru Yu, Bin Feng, Juying Wang, Chengsheng Zhang, Chao Zhou^*, Yiqiang Li^*. Integrated transcriptome and metabolome analysis revealed that HaMYB1 modulates anthocyanin accumulation to deepen sunflower flower color. Plant Cell Reports. 2024 Feb 43, 74.

5. Zhe Wang^#, Sen Xiang^#, Chao Zhou^* and Qing Xu. DeepMethylation: a deep learning based framework with GloVe and Transformer encoder for DNA methylation prediction. PeerJ. 2023 Sep 25:11: e16125.

6. Zhou H^#, Yan R^#, He H#, Wei X, Liu S, Guo B, Zhang Y, Liu X, Rahman SU, Zhou C^*, He Z*. Transcriptional profiling of long noncoding RNAs associated with flower color formation in Ipomoea nil. Planta. 2023 May 23;258(1):6.

7. Zhou H^#, Yuan Z^#, Han S^#, He H, Rong J, Guo D, Zhang Y, Zhang D, Liu X^*, Zhou C^*. Global Decrease in H3K9 Acetylation in Sorghum Seed Postgermination Stages. Journal of Agricultural and Food Chemistry. 2023 Apr 12;71(14):5836-5850.

8. Lanlan Zheng^#, Chao Zhou^#, Tonghui Li, Zhu Yuan, Hanlin Zhou, Yosuke Tamada,Yongheng Zhao, Jing Wang, Qian Zheng, Xincai Hao, Ping Huang, Xiangyin Luo,Xiao Xiao, Lei You, Qinhua Chen, Zhubing Hu, Xuanbin Wang, Kun Meng,Guodong Wang^*, Yonghong Zhang^*, Chen Li^*. Global transcriptome analysis reveals dynamic gene expression profiling and provides insights into biosynthesis of resveratrol and anthraquinones in a medicinal plant Polygonum cuspidatum. Industrial Crops & Products. 2021; 171(1).

9. Chao Zhou^#*, Xiaoyun Liu^#, Xinglei Li^#, Hanlin Zhou, Sijia Wang, Zhu Yuan, Yonghong Zhang, Sanhe Li, Aiqing You, Lei Zhou^*, Zhengquan He^*. A genome doubling event reshapes rice morphology and products by modulating chromatin signatures and gene expression profiling. Rice. 2021 Aug 4;14(1):72.

10. Lanlan Zheng^#, Chen Li^#, Xueping Ma, Hanlin Zhou, Yuan Liu, Ping Wang, Huilan Yang, Yosuke Tamada, Ji Huang, Chunfei Wang, Zhubing Hu, Xuening Wang, Guodong Wang, Haihong Li, Juntao Hu, Xiaoyun Liu^*, Chao Zhou^*, Yonghong Zhang^*. Functional interplay of histone lysine 2-hydroxyisobutyrylation and acetylation in Arabidopsis under dark-induced starvation. Nucleic Acids Research. 2021 Jul 21;49(13):7347-7360.

11. Chao Zhou^# Sijia Wang^#, Hanlin Zhou, Zhu Yuan, Tao Zhou, Yonghong Zhang, Sen Xiang, Fang Yang, Xiangling shen, Dechun Zhang^*. Transcriptome sequencing analysis of sorghum callus with various regeneration capacities. Planta. 2021 Jul 21;254(2):33.

12. Xiaoyun Liu, Junling Luo, Tiantian Li, Huilan Yang, Ping Wang, Lufang Su, Yu Zheng, Chun Bao, Chao Zhou^*. SDG711 Is Involved in Rice Seed Development through Regulation of Starch Metabolism Gene Expression in Coordination with Other Histone Modifications. Rice. 2021 Mar 5;14(1):25.

13. Chao Zhou^*, Hanlin Zhou, Xueping Ma, Huilan Yang, Ping Wang, Guodong Wang, Lanlan Zheng, Yonghong Zhang*, Xiaoyun Liu^*. Genome-Wide Identification and Characterization of Main Histone Modifications in Sorghum Decipher Regulatory Mechanisms Involved by mRNA and Long Noncoding RNA Genes. Journal of Agricultural and Food Chemistry. 2021 Feb 24;69(7):2337-2347.

14. Chao Zhou^*, Zhu Yuan, Xueping Ma, Huilan Yang, Ping Wang, Lanlan Zheng, Yonghong Zhang*, Xiaoyun Liu*. Accessible chromatin regions and their functional interrelations with gene transcription and epigenetic modifications in sorghum genome. Plant communications. 2021 Jan 11; 2(1): 100140.

15. Chao Zhou, Changshi Wang, Hongbo Liu, Qiangwei Zhou, Qian Liu, Yan Guo, Ting Peng, Jiaming Song, Jianwei Zhang, Lingling Chen, Yu Zhao, Zhixiong Zeng^* and Dao-Xiu Zhou^*. Identification and analysis of adenine N6-methylation sites in the rice genome. Nature Plants. 2018 Aug;4(8):554-563.

16. Shaoli Zhou^#, Xiaoyun Liu^#, Chao Zhou^#, Qiangwei Zhou, Yu Zhao, Guoliang Li, and Dao-Xiu Zhou*. Cooperation between the H3K27me3 Chromatin Mark and Non-CG Methylation in Epigenetic Regulation. Plant Physiology. 2016 Oct;172(2):1131-1141.

17. Feng Tan^#, Chao Zhou^#, Qiangwei Zhou^#, Shaoli Zhou, Wenjing Yang, Yu Zhao, Guoliang Li, and Dao-Xiu Zhou. Analysis of Chromatin Regulators Reveals Specific Features of Rice DNA Methylation Pathways. Plant Physiology. 2016 Jul;171(3):2041-54.

近五年科研项目

1. 国家自然科学面上项目，SbALKBH和SbHDA介导多肽激素影响高粱胚性愈伤再生能力的表观调控机制研究，2024.01-2027.12，主持。

2. 国家自然科学青年基金，SbALKBH1A介导DNA 6mA影响高粱胚性愈伤再生能力的机制研究，2020.01-2022.12，主持。

3. 湖北省自然科学基金计划一般面上项目，多组学解析高粱悬浮培养细胞合成3-脱氧花青素及其调控机制研究，2022.10-2024.09，主持。

4. 湖北省教育厅科学研究计划重点项目，基于m6A介导愈伤再生的表观调控机制建立高效、非基因型依赖的高粱遗传转化体系，2023.01-2025.12，主持。

5. 湖北省教育厅科学技术研究计划优秀中青年人才项目，DNA腺嘌呤修饰对高粱花粉发育的表观调控机制研究，2019.01-2020.12，主持。

6. 三峡大学高层次人才科研启动基金，2018.10-2021.09，主持。