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刘朝霞 副教授
作者: 点击数:时间:2020-11-18 16:32:05

姓名

刘祈星

联系电话

18871749669

电子邮箱

qixingliu86@ctgu.edu.cn

招收专业

化学、药学

研究方向

药物绿色合成技术,合成工艺和创新药研究

个人简介

刘祈星,博士,副教授,主要研究方向为药物绿色合成技术,合成工艺和创新药研究,目前任制药工程专业负责人,绿色制药技术与工艺研究中心副主任,5次获评三峡大学优秀教师”“优秀共产党员等荣誉称号,科研团队获评十大杰出青年荣誉称号。主持或参与国家自然科学基金、湖北省自然科学基金、湖北省教育厅科研基金、湖北省重点实验室开放基金、企业横向课题等十余个项目,其中校企合作的多个药物获批上市,特别是氯巴占成为治疗儿童难治性癫痫的国内首仿药,瑞马唑仑成为省内首个1.1类新药。获授权发明专利30余项,转化16项,发表SCI论文40余篇,获省级科研成果登记1项。

主要研究论文

1. 王金龙, 范吉霞, 刘祈星, 周海峰. 机械力促进的硫醚选择性氧化制备亚砜/. 精细化工, 2024, 41 (11): 2546-2552.

2. Yu P., Liu Q. X., Zuo L. H., Zhang X., Yin C. C., Zhou H. F. Water-mediated one-pot multi-step synthesis of chiral 1,3-diarylpropan-1-ols by the asymmetric hydrofunctionalisation of simple alkynes. Green Chemistry, 2024, 26: 4074–4078.

3. Yu P., Chen D., Liu Y., Yin C. C., Liu Q. X., Zhou H. F. Synthesis of Chiral 2-Oxazolidinones by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of 2-Oxazolones. Adv. Synth. Catal., 2024, 366: 1199–1204.

4. Zhao R., Wei Q., Huang Y., Qu Q., Liu Q. X., Zhou H. F. One‐Pot Construction of Fluorinated Chiral Alcohols via Sequential Substitution/Asymmetric Transfer Hydrogenation of α‐Bromoarylketones and Fluoroalcohols. Adv Synth Catal, 2023, 365 (14): 2410-2415.

5. Liu Q. X., Liu M., Chen J., Wang J., Zhou H. F. Synthesis of Chiral β-Hydroxy Selenides by Ruthenium-catalysed Transfer Hydrogenation of α-Aryl Selenomethyl Ketones. Asian J. Org. Chem., 2023, 12 (6): e202300132.

6. Fan J., Du Y., Zhao R., Liu Q. X., Zhou H. F. Catalyst- and additive-free chemoselective reduction of sulfoxides into sulfides using B2(OH)4 as a deoxygenative agent. Tetrahedron, 2023, 140 (29): 133411.

7. Zhao R., Wen S., Fu H., Liu M., Liu Q. X., Zhou H. F. Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen. Green Chemistry, 2022, 24: 1644-1649.

8. Wen S., Du Y., Liu Y., Cui X., Liu Q. X., Zhou H. F. Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)−H/N−H Cross-Coupling Mediated by I2/DMSO. European Journal of Organic Chemistry, 2022, 2022(4): e202101187.

9. Jiang X., Cui X., Chen J., Liu Q. X., Chen Y., Zhou H. F. Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water. Tetrahedron Letters, 2022, 90: 153627.

10. Zhang K., Liu Q. X., He R., Chen D., Deng Z., Huang N., Zhou H. F. Ruthenium-catalysed synthesis of chiral exocyclic allylic alcohols via chemoselective transfer hydrogenation of 2-arylidene cycloalkanones. Green Chemistry, 2021, 23 (4): 1628-1632.

11. 彭琛琛, 张志东, 刘祈星, 廖宗权, 周海峰, 氯巴占合成工艺改进. 中国医药工业杂志, 2021, 52 (7): 891-894.

12. Yu T., Guo M., Wen S., Zhao R., Wang J., Sun Y., Liu Q. X., Zhou H. F. Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen. RSC Advances 2021, 11 (23): 13848-13852.

13. Yang B., Fu H., Yuan J., Wen S., Wang C., Liu Q. X., Zhou H. F. Asymmetric Stepwise Reductive Amination of Aryl  N ‐Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis. Asian Journal of Organic Chemistry, 2021, 10 (11): 2950-2953.

14. 陈淡宜, 张福梅, 何丹, 张紫媚, 钟芬, 文思妙妙, 刘祈星, 周海峰. 钌催化的手性苯基/苯并噻唑甲醇的转移氢化合成. 高等学校化学学报 2020, 41 (10): 2264-2271.

15. Yang B., Cui P., Chen Y., Liu Q. X., Zhou H. F. Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction. Tetrahedron Letters 2020, 61 (46): 152530.

16. Liu Q. X., Sui Y., Zhang Y., Zhang K., Chen Y., Zhou H. F. Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol–Water. Synlett 2020, 31 (03): 275-279.

17. Jiang X., Zhang K., Zhao R., Bai D., Wang J., Li B., Liu Q. X., Zhou H. F. Metal-free one-pot synthesis of N-arylsulfonamides from nitroarenes and sodium sulfinates in an aqueous medium. Tetrahedron Letters 2020, 61 (42): 152397.

18. Zhang K. L., Yang Y. P., Liu H., Liu Q. X., Lv J. L., Zhou H. F. Enantioselective Synthesis of 2-Hydroxyalkyl Diarylphosphinates by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation. Adv Synth Catal 2019, 361 (17): 4106-4110.

19. Cui P., Liu Q. X., Wang J., Liu H., Zhou H. F. One-pot synthesis of chiral β-hydroxysulfones from alkynes via aerobic oxysulfonylation and asymmetric reduction in MeOH/H2O. Green Chemistry 2019, 21 (3): 634-639.

20. Liu Q. X., Wang C., Zhou H. F., Wang B., Lv J., Cao L., Fu Y. Iridium-Catalyzed Highly Enantioselective Transfer Hydrogenation of Aryl N-Heteroaryl Ketones with N-Oxide as a Removable ortho-Substituent. Organic Letters 2018, 20 (4): 971-974.

近五年科研项目

1. 肾上腺素原料药,SDHZ20201282020

2. 新农药创制研究与产业化关键技术绿色化开发,SDHZ20212152021

3. 五倍子系列产品精深加工技术开发,SDHZ20211132021

4. 没食子酸衍生的高端化学品开发及产业化,SDHZ20230282022

5. 降尿酸特效药托匹司他原料药研发,SDHZ20223072022

6. 单一催化体系促进的炔烃不对称氢官能化构筑手性醇/胺及其应用,222782442022

7. 麻醉镇痛镇静类创新药物研发,SDHZ20230292023

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