化学

电子邮箱

liaohz@shsmu.edu.cn

招收专业

药物化学，有机化学

研究方向

天然产物结构优化及其抗肿瘤活性研究

个人简介

上海交通大学医学院附属仁济医院，药学部海洋药物研究中心，副研究员

主要从事合成化学与药物化学研究，采用新颖的化学反应完成海洋天然产物全合成，并结合计算机辅助药物设计技术对天然产物进行结构优化从而获得活性更优的类天然产物。

研究课题分别受国家自然科学基金重点和青年项目资助，先后在Advanced Science, Chemical Science, Green Chemistry, ACS Applied Materials Interfaces，Organic Letters 等期刊上发表SCI文章20余篇。

获得上海市浦江人才计划A类。

主要研究论文

1. Bo Liu; Qiong Wang; Bin Cheng; Taimin Wang; Hongze Liao*; Hou-Wen Lin*; Metal- and photosensitizer-free cross-dehydrogenative coupling through photoinduced energy transfer, Green Chemistry, 2024, DOI: 10.1039/d3gc03983h.

2. Zhiyou Su^#; Jia Zhang^#; Hou-Wen Lin*; Hongze Liao*, Synthesis of 1,4-Dicarbonyl Compounds via Visible-Light-Induced Decarboxylative Radical Cascade Reactions, Advanced Synthesis &Catalysis, 2023, 365, 3444.

3. Bo Liu^#; Shuping Wang^#; Changhao Bian; Hongze Liao*; Hou-Wen Lin*; Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes, Chinese Journal of Chemistry, 2021, 39,1905.

4. Liting Wang^#, Qing Shen^#, Hongze Liao*, Hao Fu, Qi Wang, Jian Yu, Wei Zhang, Chuanrong Chen, Yang Dong, Xupeng Yang, Qianqian Guo, Jiali Zhang, Jian Zhang, Wei Zhang, Houwen Lin*, Yourong Duan*, Advanced Science, 2021, 8, 2003558.

5. Zhiyou Su^#; Bo Liu^#; Hongze Liao*; Hou-Wen Lin, Synthesis of N-Heterocycles by Reductive Cyclization of Nitroalkenes Using Molybdenum Hexacarbonyl as Carbon Monoxide Surrogate, European Journal of Organic Chemistry, 2020, 2020, 4059.

6. Fan Yang; Yuan Gao; Yung-Ting Chang; Yike Zou; K. N. Houk; Jing-Rong Lu; Jing He; Wei-Zhuo Tang; Hongze Liao; Hua Han*; Hou-Wen Lin*; Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma, Journal of Natural Products, 2019, 83, 3758.

7. Zhirong Zhu, Xiaoyan Chen, Hongze Liao, Li Li, Haojian Yang, Qi Wang,* Wei-Hong Zhu*, Microalbuminuria sensitive near-infrared AIE probe for point-of-care evaluating kidney diseases, Aggregate, 2024, DOI: 10.1002/agt2.526.

8. Zhirong Zhu, Qi Wang*, Hongze Liao, Ming Liu, Zhenxing Liu, Youheng Zhang, Wei-Hong Zhu*, Trapping endoplasmic reticulum with amphiphilic AIE-active sensor: achieving high targeting via specific interaction of ATP-sensitive potassium (K_ATP), National Science Review, 2020, 8, nwaa198.

近五年科研项目

1) 国家重点研发计划，基于AI的活性先导化合物优化与筛选子课4，2022YFC2804104,  2022年11月 至 2025年10月, 20万，在研，主持。

2) 国家自然科学基金青年科学基金项目, 81903499, 苯并[de][1,6]萘啶酮类新型ChK1抑制剂的 设计合成和药理活性研究, 2020-01-01 至 2022-12-31, 21万元, 结题, 主持。

3) 国家自然科学基金面上项目, 82073713, 靶向TNKS-USP25互作新抗霉素类天然活性分子的结 构优化及抗APC/KRAS突变结直肠癌作用机制研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 参与。

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