药学

电子邮箱

liuhanghang@ctgu.edu.cn

招收专业

化学；药学

研究方向

功能纳米材料、药物靶向递送、天然产物纳米药物开发与利用

个人简介

刘航航，女，1992年，博士，校聘副教授。2015年6月于河南师范大学获理学学士学位，2018年6月于苏州大学获理学硕士学位，2022年6月于苏州大学放射医学与辐射防护国家重点实验室获医学博士学位，2022年7月以青年拔尖人才计划引进三峡大学生物与制药学院。主要从事多功能纳米药物的构建、智能靶向型纳米载药系统的设计、天然产物纳米酶的生物医学应用研究，近5年在J. Am. Chem. Soc.、Adv. Mater.、Biomaterials、Nano Today、Adv. Funct. Mater.、Anal. Chem.、J. Mater. Chem. B等国际知名期刊发表SCI论文30余篇，封面论文2篇。主要讲授课程《物理化学II/III》、《物理化学实验》。

主要研究论文

1. Wanyue Fu^#; Zhongshi Huang^#; Weiqi Li; Lingling Xu; Miaomiao Yang; Yan Ma; Hanghang Liu*; Haisheng Qian*; Wanni Wang*, Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease. Bioactive Materials. 2025, 46, 118-133. (IF=18.0, 1区TOP)

2. Hanghang Liu^#; Menglong Hua^#; Yaobao Han; Li Yang; Zhongshi Huang; Jiabing Ran; Huimin Wang; Feng Ren*; Changying Yang*; Zhen Li*, Hijacking endogenous iron to amplify lysosomal-mitochondrial cascade damage for boosting anti-tumor immunotherapy. Biomaterials 2025, 316, 122983. (IF=12.8，1区TOP)

3. Hanghang Liu^#; Qing Zheng^#; Jiaxin Yuan; Yifan Gao; Tingting Wang; Hao Zhang; Zhen Li*. Modulating SQSTM1/p62-dependent selective autophagy of neurons by activating Nrf2 with multifunctional nanoparticles to eliminate α-synuclein aggregates and boost therapy of Parkinson’s disease. Nano Today 2023, 49: 101770. (IF=13.2，1区)

4. Hanghang Liu; Menglong Hua; Qing Zheng; Yifan Gao; Zhen Li*. Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles. MedComm – Biomaterials and Applications 2023, 2 (2): e47.

5. Hanghang Liu; Yaobao Han; Tingting Wang; Hao Zhang; Qi Xu; Jiaxin Yuan; Zhen Li*. Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles. Journal of the American Chemical Society 2020, 142 (52): 21730-21742. (IF=16.383，封面，1区TOP)

6. Hanghang Liu; Feng Ren; Xingguo Zhou; Changqiu Ma; Tingting Wang; Hao Zhang; Qiao Sun*; Zhen Li*. Ultra-Sensitive Detection and Inhibition of the Metastasis of Breast Cancer Cells to Adjacent Lymph Nodes and Distant Organs by Using Long-Persistent Luminescence Nanoparticles. Analytical Chemistry 2019, 91 (23): 15064-15072. (IF=8.008，封面，1区TOP)

7. Hanghang Liu; Feng Ren; Hao Zhang; Yaobao Han; Huizhu Qin; Jianfeng Zeng; Yong Wang; Qiao Sun*; Zhen Li*; Mingyuan Gao. Oral administration of highly bright Cr³⁺ doped ZnGa₂O₄ nanocrystals for in vivo targeted imaging of orthotopic breast cancer. Journal of Materials Chemistry B 2018, 6 (10): 1508-1518. (IF=7.571)

8. Hanghang Liu^#; Sepehr Talebian^#; Kara L. Vine; Zhen Li*; Javad Foroughi*. Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy. Nano Select 2022, 3 (1): 212-226.

9. Yifan Gao; Hanghang Liu; Qing Zheng.; Li Yang; Guozhi Cao; Jiaxin Yuan; Shijun Hu; Zhen Li, Modulating efficient differentiation of neural stem cells into neurons by using plasmonic nanoparticles and the NIR II irradiation to boost therapy of Parkinson’s disease. Nano Today 2024, 57, 102392.（IF=13.2，1区）

10. Jiaxin Yuan; Hanghang Liu; Hao Zhang; Tingting Wang; Qing Zheng; Zhen Li*. Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease. Advanced Materials 2022, 34 (11): 2108435. (IF=32.086，封面，1区TOP)

11. Qing Zheng; Hanghang Liu; Hao Zhang; Yaobao Han; Jiaxin Yuan; Tingting Wang; Yifan Gao; Zhen Li*. Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease. Advanced Science 2023, 10 (22): 2300758.（IF=14.3，1区TOP）

12. Bolin Bao; Hanghang Liu; Yaobao Han; Liyao Xu; Wei Xing*; Zhen Li*. Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury. ACS Applied Materials & Interfaces 2023, 15 (13): 16460-16470.

13. Feng Ren; Hanghang Liu; Hao Zhang; Zhilin Jiang; Bing Xia; Cécile Genevois; Tao He; Mathieu Allix; Qiao Sun; Zhen Li*; Mingyuan Gao. Engineering NIR-IIb fluorescence of Er-based lanthanide nanoparticles for through-skull targeted imaging and imaging-guided surgery of orthotopic glioma. Nano Today 2020, 34: 100905. (IF=18.962)

14. Xingguo Zhou; Hanghang Liu; Yanhui Zheng; Yaobao Han; Tingting Wang; Hao Zhang; Qiao Sun; Zhen Li*. Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor. ACS Applied Materials & Interfaces 2020, 12 (4): 4231-4240. (IF=8.3)

15. Changqiu Ma; Hanghang Liu; Feng Ren; Zheng Liu; Qiao Sun; Chongjun Zhao*; Zhen Li*. The Second Near-Infrared Window Persistent Luminescence for Anti-Counterfeiting Application. Crystal growth & design 2020, 20 (3): 1859-1867. (IF=4.01)

近五年科研项目

(1) 国家自然科学基金青年科学基金，30万，2025.01-2027-12，主持；

(2) 湖北省自然科学基金（青年项目），8万，2024.03-2026.03，主持；

(3) 放射医学与辐射防护国家重点实验室开放课题，3万，2023.08-2024.12，主持；

(4) 三峡大学高层次人才科研启动及平台建设经费（拔尖人才），70万，2022.08-2025.07，主持。

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