He Haibo's Resume
Curriculum vitae
Photo
Personal Information
Family name:He Given Name: Haibo
Date of Birth: January 25,1972 Birth Place: Hubei, P.R. China
Sex:Male Marital Status: Married
Nationality: Chinese
Communications: Moibile Phone+86-13545708972
Office: +86-717-6397980 Fax: +86-717-6397980
E-mail: hjy219@126.com
Mobile: 13469861312
Address: 8 University Avenue, 443002Yichang, Hubei province, P.R. China
Areasof Interest
· Extraction andSeparation of Natural Drugs and Development of New Products;
· Cancer phytotherapy andcancer adjuvant therapy development;
· Cardio-cerebrovasculardisease phytotherapy;
· Digestive systemdisease phytotherapy;
· Functional foodresearch and development.
Experience
Apr, 2018~Present: Visiting Scholar,Department of MedicinalResources, Institute of Natural Medicine, University ofToyama.
Dec, 2011~Apr, 2018: Teacher and researcher, Hubei Key Laboratory of Natural ProductsResearch and Development,College ofBiological and Pharmaceutical Sciences, China Three Gorges University.
Jul, 2008~Nov, 2011: Teacher and researcher, Collegeof Medical Sciences, ChinaThree Gorges University.
Jul, 1995~Aug, 2000:Pharmacist, Ezhou First People’s Hospital, Ezhou, China.
Education
Jul, 2006~Jun, 2008:Postdoctoral researcher, Bioinformatics, Zhejiang University, Hangzhou, China.
Sep, 2000~Jun, 2006: Doctor,Pharmacology, China Pharmaceutical University, Nanjing, China.
Sep, 2000~Jun, 2003: Master,Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha.
Sep, 1991~Jun, 1995: Bachelor,Chinese Materia Medica, China Three Gorges University, Yichnag, China.
Honors
Excellent postgraduate student leader.
Awards
Excellent postdoctoral students in ZhejiangUniverstiy (2008);
First Prize ScholarshipinChina Pharmaceutical University(2005, 2006);
First Prize ScholarshipinHunan University of Chinese Medicine(2002, 2003).
SelectedArticles in Recent Years
1. He Haibo, Li Xiaomei, Li Daojun, Ding Yonghong,Zhang Yongfeng, Xu Haiyan, Feng Minlu, Xiang Changqing, Zhou Jigang, ZhangJihong, Liu Hongjun, Chen Maohua. Saponins from Rhizoma Panacis Majorisattenuate myocardialischemia/reperfusion injury via the activation oftheSirt1/FoxO1/Pgc-1α and Nrf2/antioxidant defense pathways in rats[J].Pharmacogn Mag, 2018,14(56):297-307.
2. He Haibo, Li Xiaomei, Yu Haili, ZhuShu, He Yumin, Komatsu Katsuko, Guo Dongyan, Li Xiaoqin, Wang Junzhi, LuoHuajun, Xu Daoxiang, Zou Kun. Gastroprotectiveeffect of araloside A on ethanol and aspirin-induced gastric ulcer in mice:involvement of H+/K+-ATPaseandmitochondrial- mediated signaling pathway. J Nat Med, 2018, doi:10.1007/s11418-018- 1256-0.
3. TangHongbo, Jiang Ziwen, He Haibo, Li Xiaoqin, Hu Haipeng, Zhang Ning, DaiYinmei, Zhou Zhimin. Uptake and transport of pullulan acetate nanoparticles inthe BeWo b30 placental barrier cell model. Int J Nanomedicine, 2018, 13:4073-4082.
4. Wang Junzhi,Chen Beiyan, Hu Fang, Zou Xueling, Yu Haili, Wang Jinyu, Zhang Hongqi, He Haibo,Huang Wenfeng. Effect of Hispolon from Phellinus lonicerinus (Agaricomycetes)on Estrogen Receptors, Aromatase, and Cyclooxygenase II in MCF-7 Breast CancerCells.Int J Med Mushrooms, 2017,19(3):233-242.
5. Wang Junzhi,Zhang Pan, He Haibo*, Se Xinxin, Sun Wenjun, Chen Beiyan, Zhang Lin, YanXiming, Zou Kun.Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrillattenuates inflammatory responses through inhibiting LPS-induced activation ofPI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells.Naunyn Schmiedebergs ArchPharmacol, 2017, 390(8):845-856.
6. BaiCaihong, Yang Xiaojiao,ZouKun, He Haibo*,WangJunzhi, Qin Huilin,Yu Xiaoqin ,Liu Chengxiong, Zheng Juyan, Cheng Fan, ChenJianfeng. Antiproliferative effect of RCE-4 from Reineckia carnea on humancervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathwayand NF-κB activation. Naunyn Schmiedebergs Arch Pharmacol, 2016, 389(6):573-584.
7. Zheng Juyan,Wang Qian, Liu ZhaoXia, Liu Chengxiong, Guo Zhiyong, Zhang Hongqi, He Haibo,Tu Xuan, Zou Kun.Two new steroidal glycosides with unique structural feature of14α-hydroxy-5β-steroids from Reineckia carnea.Fitoterapia, 2016, 115:19-23.
8. Liu Chengxiong,Yu Xiaoqin, Guo Zhiyong, He Haibo, Tu Xuan, Deng Zhangshuang, Zou Kou.Structuralelucidation and NMR spectral assignments of paraconfuranones I-M from theinsect-associated fungus Paraconiothyrium brasiliense.Magn Reson Chem, 2016, 54(11):916-921.
9. Lu Xiaofeng,Yang Zheng, Huang Nianyu, He Haibo, Deng Weiqiao, Zou Kun.Synthesis andcytotoxic activities of 2-substituted (25R)-spirostan-1,4,6-triene-3-ones via ring-opening/eliminationand 'click' strategy. Bioorg Med Chem Lett, 2015, 25(17):3726-3729.
10. Wang Junzhi, Sun Wenjun, Luo Huajun,He Haibo, Deng Weiqiao, Zou Kou, Liu Can, Song Jing, Huang Wenfeng.Protectiveeffect of eburicoic acid of the chicken of the woods mushroom, Laetiporussulphureus (higher basidiomycetes), against gastric ulcers in mice. Int JMed Mushrooms, 2015, 17(7):619-626.
11. Zhang Hongqi, Deng Zhangshuang,Guo Zhiyong, Peng Yan, Huang Nianyu, He Haibo, Tu Xuan, Zou Kun.Effect of culture conditions on metabolite productionof Xylaria sp.Molecules, 2015, 20(5):7940-7950.
12. Zhang Qioayin, Wang Junzhi, HeHaibo*, Liu Hongbin, Yan Ximing, Zou Kun. Trametenolic acid B reversesmultidrug resistance in breast cancer cells through regulating the expressionlevel of P-glycoprotein.Phytother Res, 2014, 28(7):1037-1044.
13. Wei Na, Zhang Changcheng, HeHaibo*, Wang Ting, Liu Zhaoqi, Liu Guangyao, Sun Zhiwei, Zhou Zhiyong, BaiCaihong, Yuan Ding. Protectiveeffect of saponins extract from Panax japonicus on myocardial infarction:involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signallingpathways and inhibition of inflammation.J Pharm Pharmacol, 2014, 66 (11):1641-1651.
14. Wang Sa, He Haibo*, XiaoShuzhang, Wang Jun zhi, Bai Caihong, Na Wei, Kun Zou. Comparison between thecardioprotective effects of labeled and unlabeled oleanoic acid with new BOPIMdye on primary neonatal rat cardiomyocytes following hypoxia/reoxgenationinjury. Pharmacological Rep, 2014, 66 (4):677-685.
15. Huang Shaolan, He Haibo*,Zou Kun, Bai Caihong, Xue Yanhong, Wang Junzhi, Chen Jianfeng. Protectiveeffect of tomatine against hydrogen peroxide-induced neurotoxicity inneuroblastoma (SH-SY5Y) cells. J Pharm Pharmacol, 2014, 66(4): 844-854.
16. Yuan Ding, Wang Hongwu, HeHaibo*, Jia Liangliang, He Yumin, Wang Ting, Zeng Xiao, Li Yuzhou, LiShouchao, Zhang Changcheng. Protective Effects of total Flavonoids fromEpimedium on the male mouse reproductive system against cyclophosphamide-inducedoxidative injury by up-regulating the expressions of SOD3 and GPX1. PhytotherRes, 2014, 28(1):88-97.
17. Jin Guilan, Qin Huilin, HeHaibo*, Cheng Fan, Gong Dachun, Xu Bang, Jia Liangliang, Xi Wei, WangHongwu, Xiang Xiangfei. Neuroprotective effects of breviscapine againstoxidative-stress- Induced cell death in PC12 cells: Involvement of Nrf2/HO-1 pathway.Medicine Sciences and Bioengineering, 2014, 277-282.
18. Bai Caihong, He Haibo*,Cheng Fan, Zou Kun, Wang Junzhi, Liu Guangyao, Deng Wei, Chen Zhifeng,Chen Xiao, Chen Jianfeng. A steroidal saponin RCE-4 inhibitslipopolysaccharide-stimulated inflammatory responses via blockingPI3K/Akt-mediated NF-κB activation in RAW264.7 cells. Applied Mechanics andMaterials, 2014, 568-570: 1901-1906.
19. Wei Na, Yuan Ding, He Haibo*,Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponinsfrom Panax japonicas reduces myocardial infarction induced ReactiveOxygen Species production and cardiomyocyte apoptosis via activation of theNrf-2 pathway. Advanced Materials Research, 2014, 881-883: 339-346.
20. Bai Caihong, He Haibo*,Cheng Fan, Wang Junzhi, Chen Xiao, Zou Kun, Liu Guangyao, Chen Zhifeng, ChenJianfeng. Cardioprotective effects of saponins from Rhizoma Panacis Majoris onmyocardial ischemia/reperfusion injury via scavenging excessive reactive oxygenspecies. Advanced Materials Research, 2014, 165-172: 165-172.
21. Zhang Jihong, ShiMengqiong,He Haibo*, Bai Caihong, Wang Junzhi, Cheng Fan, LiuGuangyao, Deng Wei, Zou Kun, Chen Zhifeng. Hepatoprotective effects of saponinsfrom Rhizoma Panacis Majoris on hepatic fibrosis induced by carbontetrachloride in rats. Applied Mechanics and Materials, 2014, 568-570,1915-1920.
22. Zhang Qiaoyin, Huang Nianyu,Wang Junzhi, Luo Huajun, He Haibo, Ding Mingruo, Deng Weiqiao, Zou Kun.TheH+/K+-ATPase inhibitory activities of Trametenolic acid Bfrom Trametes lactinea (Berk.) Pat, and its effects on gastric cancercells.Fitoterapia, 2013, 89:210-217.
23. Wang Guiping, Huang Wenfeng, HeHaibo, Fu Xuejiaoo, Wang Junzhi, Zou Kun, Chen Jianfeng.Growth inhibitionand apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanolsaponin derivative from natural medicines.Int J Mol Med, 2013, 31(1):219-224.
24. Wei Na, Yuan Ding, He Haibo*,Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponinsfrom Panax japonicas reduces myocardial infarction induced Reactive OxygenSpecies production and cardiomyocyte apoptosis via activation of the Nrf-2pathway. Advanced Materials Research, 2013, 784-789: 367-371.
25. Deng gaigai, Wang junzhi, ZhangQiaoyin, He Haibo*, Wu Fangfang, Feng Tianyan, Zhou Jigang, Zou Kun,Masao Hattoric. Hepatoprotective effects of Phloridzin on hepatic fibrosisinduced by carbon tetrachloride against oxidative stress-triggered damage andfibrosis in rats. Biol. Pharm. Bull, 2012, 35(7):1118-112.
26. Chen Tao, Hu Wei, He Haibo,Gong Zipeng, Wang Jing, Yu Xueqin, Ai Ting, Zhan Ling.A study on the mechanismof cinobufagin in the treatment of paw cancer pain by modulating local β-endorphinexpression in vivo. Evid Based Complement Alternat Med, 2013:851256.
27. Mao Miaofu, Xiao Shuzhang, HeHaibo,CaoQiong, Zou Kun. Fluorescent labeling of oleanolic acidusing ‘‘click’’chemistry. Heterocycl Commun, 2013, 19:239-243.
28. He Haibo, Xu Jia, Xu Yuanding, ZhangChangcheng, Wang Hongwu, He Yumin, Wang Ting, Yuan Ding. Cardioprotectiveeffects of saponins from Panax japonicus on acute myocardial ischemia againstoxidative stress-triggered damage and cardiac cell death in rats. JEthnopharmacol, 2012, 140 (1). 73-82.
29. He Haibo, Huang Nianyu, Shi Mengqiong,Yang Wenyan, Zhang Qiaoyin, Xiong Yanqiang. Neuroprotective effects of saponinfrom Panacis majoris rhizome against cerebral ischemia/reperfusion injury viascavenging overgeneration and accumulation of ROS and inducing nucleartranslocation of Nrf2. Mol Neurobiol, 2012, 46(Supple1):S18-S19.
