Nianyu Huang's Resume
Gender:Male
Contact: Tel: +86-135 4570 8972
Email:huangny@ctgu.edu.cn
Office: S-3301
Lab: S-3603
EducationBackground
Visiting scholar– Methodology study in sugar chemistry (5/2015 - 5/2016)
Division of Chemistry and BiologicalChemistry
School of Physical & MathematicalSciences
Nanyang Technological University
Ph.D. - Pesticide MoleculeDesign and Synthesis(9/2006 - 6/2009)
Key Lab of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry
Central China Normal University
Title of Dissertation:“Synthetic Methods and Properties of Novel Guaninesand other N-heterocycle Derivatives” (Supervisor: Prof.Ming-wu Ding)
M. S. – Organic Chemistry(9/2003 - 6/2006)
(Successive postgraduate and doctoralprograms of study; Supervisor: Prof. Ming-wu Ding)
College of Chemistry, Central China Normal University
B. S.– Applied Chemistry(9/1999 - 6/2003)
College ofChemistry, Central China Normal Universit
Scientificresearchitems
l National Natural Science Foundation of China(21272136)
Design, synthesis and biological evaluationof natural bioactive sequiterpene bisabolonalone derivatives as anti-ulcerdrugs.
l Youth Talent Development Foundation of China ThreeGorges University
Design and synthesis of anti-cancer naturalproducts, including flavonoid, alkaloidf triterpenoid and saponin.
l Research projects committed by pharmaceutical companies(SDHZ2015072 / 2017121 / 2018061)
Research and developmentof the synthesis technology of anti-psoriatic drug calcipotriol, anti-cholestaticdrugobeticholic acid and anti-diabetic drugscalcium dobesilate.
Research Interests
l Structure modification of natural products
l Organic synthesis in heterocyclic chemistry
Research Publications
i. Publicatedarticles in recent years
1）YuanYao, Cai-Ping Xiong, Ya-Ling Zhong, Guo-Wei Bian, Nian-Yu Huang*,Long Wang, Kun Zou. Intramolecular and Ferrier Rearrangement Strategy for theConstruction of C1-β-D-xylopyranosides: Synthesis, Mechanism and Biological ActivityStudy. Adv. Synth. Catal. 2019, 361, 1012-1017.[2018 Impact Factor: 5.451]
2）NianyuHuang, Hongze Liao, Hui Yao, Tianpeng Xie, ShashaZhang, Kun Zou*, Xue-Wei Liu*. Diastereoselective Synthesis of C-VinylGlycosides via Gold(I)-Catalyzed Tandem 1,3-Acyloxy Migration/FerrierRearrangement. Organic Letters2018, 20, 1, 16-19. [2018 Impact Factor: 6.555]
3）LongWang, Yi-Bi Xie, Nian-Yu Huang*, Jia-Ying Yan, Wei-Min Hu, Ming-GuoLiu, and Ming-Wu Ding*. Catalytic aza-Wittig reaction of acid anhydride for thesynthesis of 4H-benzo[d][1,3]oxazin-4-ones and4-benzylidene-2-aryloxazol-5(4H)-ones. ACS Catal. 2016, 6(6), 4010-4016.[2018 Impact Factor: 12.221]
4）Xiao-Feng Lu, Zheng Yang, Nian-Yu Huang*, Hai-Bo He, Wei-QiaoDeng, Kun Zou*. Synthesis and cytotoxic activities of 2-substituted(25R)-spirostan-1,4,6-triene-3-ones via ring-opening/elimination and “click”strategy. Bioorg. Med. Chem. Lett. 2015, 25(17), 3726-3729.[2018 Impact Factor: 2.448]
5）NianyuHuang, Wenbin Wang, Lei Chen, Huajun Luo*,Junzhi Wang, Weiqiao Deng, Kun Zou. Design, synthesis and biological evaluationof bisabolonalone oxime derivatives as potassium-competitive acid blockers(P-CABs). Bioorg. Med. Chem. Lett. 2016, 26(9), 2268-2272.[2018 Impact Factor: 2.448]
6）Rong-KunLi, Quan-Li Yang, Yi Liu, Dong-Wei Li, Nian-Yu Huang*, Ming-GuoLiu. A novel and green synthesis of indolone-N-amino acid derivatives via thePasserini three-component rections in water. Chinese Chem. Lett.2016, 27(3), 345-348.[2018 Impact Factor: 3.839]
ii. Issued patents inrecent years
1)NianyuHuang, Junzhi Wang, Huajun Luo,Ximing Yan, LingWu, Chengqiao Cao, Zhangshuang Deng. A phenolic compound andits use. CN 201410495358.6
2)NianyuHuang, Junzhi Wang, Chengqiao Cao,Wenbin Wang, Ximing Yan, Fan Zhang. Tetrahydrobenzothiazole-7-ketoxime drugs,preparation methods and application. CN 201510111459.3
3) NianyuHuang, Mingguo Liu, Rongkun Li, JunzhiWang, Quanli Yang, Fan Zhang. A tetrahydroindole-4-ketoxime drug, itspreparation method and application. CN 201510118757.5
4) NianyuHuang, Junzhi Wang, Kun Zou,Huajun Luo, Hubiao Fang, Wenbin Wang, Fan Zhang. A bistriazole acid inhibitor,its preparation method and application. CN 2015101276.0
5)NianyuHuang, Wenbin Wang, LeiJin,FanZhang, Junzhi Wang, Kun Zou, Ximing Yan. Tetrahydrobenzofuran-4-ketoximetriazole drug, preparation method and application. CN 201510111498.3
