Curriculum Vitae of Associate Professor Nengzhong Wang
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 Daxue Road, Yichang 443002, P. R. China, E-mail: wangnz@ctgu.edu.cn
I obtained my Ph.D. degree under the mentorship of Prof. Xuefeng Jiang at East China Normal University (ECNU) in 2018. From 2018 to 2022, I was a postdoc research fellow under the guidance of Prof. Yixin Lu at National University of Singapore (NUS) in the field of novel phosphine-catalyzed asymmetric reactions and their applications in the total synthesis of biologically active alkaloids. In 2022, I started my independent career as an associate professor at China Three Gorges University (CTGU). My research interest is devoted to phosphine catalysis, organocatalysis, and natural product synthesis.
PROFESSIONAL EXPERIENCE
2022.03 – Present Associate Professor
College of Biological and Pharmaceutical Sciences,
China Three Gorges University, China
2018.10 – 2022.01 Research Fellow
Department of Chemistry
National University of Singapore, Singapore
EDUCATIONS
2014.09 – 2018.06 Doctoral Student
School of Chemistry and Molecular Engineering
East China Normal University, China
2011.09 – 2018.06 Master Student
Faculty of Life Science and Technology
Kunming University of Science and Technology, China
2007.09 – 2011.06 Undergraduate
Pharmacy
Hubei University of Chinese Medicine, China
LIST OF PUBLICATIONS
1. Gang Chen,‡ Guangjie Nie,‡ Linxuan Li,* Jie Fu, Hui Yao, Nianyu Huang,* and Nengzhong Wang* Atom-Controlled Divergent Synthesis of Spiro and Fused Rings via Base-Catalyzed Chemoselective Annulation. Org. Chem. Front. 2025, 12, DOI: 10.1039/D4QO02400A.
2. Yufei Zhang, Jing Chen, Hui Yao,* Yuanbin Wang, Hongyu Liu, Long Wang, Nianyu Huang,* and Nengzhong Wang* Phosphine-Catalyzed Divergent γ,γ- and ε,γ-Umpolung Domino Additions of Bisoxindoles with Allenoates: Construction of Vicinal All-Carbon Quaternary Stereocenters and Formal Total Synthesis of Dimeric Cyclotryptamine Alkaloids. Chin. J. Chem. 2025, 43, 995-1000.
3. Yi Li,‡ Xianfei Hu,‡ Boning Li, Sen Zhang, Hui Yao,* Xiao Xiao, Nianyu Huang,* and Nengzhong Wang* Controllable Phosphine-Catalyzed Three-Component Domino Reaction of Activated Alkenes with Morita−Baylis−Hillman (MBH) Carbonates: Divergent Synthesis of Densely Functionalized Cyclopentanes and Diquinanes. Org. Lett. 2024, 26, 10651–10657.
4. Boning Li,‡ Xianfei Hu,‡ Hui Yao,* Yi Li, Dan Xu, Nianyu Huang,* and Nengzhong Wang* Pyridine-Catalyzed Chemoselective Four-Component Cascade Reaction of Aromatic Aldehydes, Malononitrile/Cyanoacetates, MBH Carbonates and Alcohols. Org. Lett. 2024, 26, 7576–7583.
5. Mengting Tan,‡ Yunping Zheng,‡ Sen Zhang, Hui Yao,* Xin Yan, Xing Zhao, Mingguo Liu, Nianyu Huang,* and Nengzhong Wang* Base-Controlled Chemodivergent [4 + 1] and [2 + 1]/[4 + 2] Annulations of o Aminochalcones with γ-Bromocrotonates. Org. Lett. 2024, 26, 9203–9209.
6. Zhengyang Chen,‡ Dan Xiong,‡ Nengzhong Wang,* Yufei Zhang, Hui Yao, Jinkun Zhang, Nianyu Huang* and Kun Zou* Concise synthesis of Pyrrolo[3,4-c]quinolines via a P(NMe2)3- Catalyzed [4 + 2] Annulation followed by a Zn/AcOH-Mediated Reduction-Hydroamination- Isomerization. Org. Chem. Front. 2024, 11, 2762–2767.
7. Shuhui Li,‡ Xiaoxuan Li,‡ Hui Yao,* Mengting Tan, Dan Xu, Nianyu Huang* and Nengzhong Wang* Straight-Chain ω-Amino-α,β-Unsaturated Carbonyl Compounds: Versatile Synthons for the Synthesis of Nitrogen-Containing Heterocycles via Organocatalytic Reactions. Org. Chem. Front. 2024, 11, 236–253.
8. Zefeng Jin, Fangfang Zhang, Xiao Xiao, Nengzhong Wang,* Xin Lv* and Liejin Zhou* Recent Advances in N-Heterocyclic Carbene (NHC) Catalyzed Fluorination and Fluoroalkylation. Org. Chem. Front. 2024, 11, 2112–2113.
9. Rui Xie,‡ Jing Xu,‡ Haolin Shi, Chenyu Xiao, Nengzhong Wang,* Nianyu Huang,* and Hui Yao* Stereocontrolled Synthesis of Aryl C-Nucleosides under Ambient Conditions. Org. Lett. 2024, 26, 5162–5166.
10. Yixuan Liu,‡ Yuan Wang,‡ Jie Chen, Nengzhong Wang*, Nianyu Huang*, and Hui Yao* Stereoselective Synthesis of β-S-Glycosides via Palladium Catalysis. J. Org. Chem. 2024, 89, 8815–8827.
11. Xinyu Gao, Keke Ren, Lijuan Ma, Nengzhong Wang*, Nianyu Huang*, Hui Yao* Highly Regio-/Stereoselective Synthesis of Carbohydrates with Unsaturated Glycosyl Donors under Mild Conditions. Synlett 2024, DOI: 10.1055/a-2348-2803.
12. Fakai Zou, Nengzhong Wang, Hui Yao*, Hui Wang, Mingguo Liu, Nianyu Huang* Regio- and Stereo-selective Synthesis of 1β-/3R-Aryl Thiosugar Chin. J. Org. Chem. 2024, 44, 593–604.
13. Tao Xiong,‡ Zhen Cao,‡ Jiarui Gu, Nengzhong Wang, Mingguo Liu,* Hui Yao* Stereoselective Synthesis of 3-Sulfone Sugars via Cobalt Catalysis. J. Carbohydr. Chem. 2024, 43, 70–89.
14. Mingyu Hou, Yimin Xiang, Jingyu Gao, Jingyu Zhang, Nengzhong Wang,* Haolin Shi, Nianyu Huang,* and Hui Yao* Stereoselective Synthesis of 2-Deoxy Glycosides via Iron Catalysis. Org. Lett. 2023, 25, 832–837.
15. Xinyuan Wang,‡ Yueyue Shan,‡ Hui Miao, Xiao Xiao, Nengzhong Wang,* Xin Lv, * and Liejin Zhou* Selective N-N or N-S Bond Cleavage of 1-Trifluoromethyl Benzotriazoles Enables Divergent Synthesis of 1,2,4-Benzotriazines and Benzotriazoles. Org. Chem. Front. 2023, 10, 5138–5143.
16. Yifei Huang,‡ Mengting Tan,‡ Nengzhong Wang,* Yufei Zhang, Hui Yao, Xiao Xiao, Nianyu Huang,* and Kun Zou* Highly Regio- and Diastereoselective Phosphine-Catalyzed [2 + 4] Annulation of Benzofuran-Derived Azadienes with Allyl Carbonates: Access to Spiro[benzofuran-cyclohexanes]. J. Org. Chem. 2023, 88, 13030–13041.
17. Xiaoxiao Zhao,‡ Zhentao Zhang,‡ Jing Xu, Nengzhong Wang,* Nianyu Huang* and Hui Yao* Stereoselective Synthesis of O-Glycosides with Borate Acceptors. J. Org. Chem. 2023, 88, 11735–11747.
18. Jingyu Gao,‡ Yi Li,‡ Nengzhong Wang,* Zhiyue Li, Nianyu Huang,* and Hui Yao* One-Pot Stereoselective Synthesis of 2,3,4-Trihydroxy-β-N-Pyranosides from Glycals and Amines. Adv. Synth. Catal. 2023, 365, 2350–2355.
19. Yanyan Wang,‡ Zhen Cao,‡ Nengzhong Wang,* Ming-Guo Liu, Haifeng Zhou, Long Wang, Nianyu Huang,* and Hui Yao* Palladium-Catalyzed Stereospecific S-Glycosylation by Allylic Substitution. Adv. Synth. Catal. 2023, 365, 1699–1704.
20. Jingrui Wang,‡ Yongkui Feng,‡ Nengzhong Wang, Nianyu Huang,* and Hui Yao* Pd-Catalyzed Stereoselective Synthesis of Nitroalkyl β-C-Glycosides. Chin. J. Org. Chem. 2023, 43, 3216–3225.
21. Xiaohui Chen, Neng-Zhong Wang, Ya-Min Cheng, Xianqiang Kong,* and Zhong-Yan Cao* Recent Advances in Electro- or Photochemical Driven Transformations via Cleavage of C-N Bond of Quaternary Ammonium Salts. Synthesis 2023, 55, 2833–2842.
22. Nengzhong Wang, Yimin Lang, Junjie Wang, Zugen Wu, and Yixin Lu* Phosphine-Catalyzed Sequential [3 + 2]/[3 + 2] Annulation between Allenoates and Arylidenemalononitriles for the Enantioselective Construction of Bicyclo[3,3,0]octenes and Cyclopenta[c]quinolinones. Org. Lett. 2022, 24, 3712–3716.
23. Nengzhong Wang,* Xiao Xiao, Cheng-Xiong Liu, Hui Yao,* Nianyu Huang, and Kun Zou* Recent Advances in the Total Synthesis of Aspidosperma and Kopsia Alkaloids Using Tetracyclic Pyridocarbazoles as Versatile Building Blocks. Adv. Synth. Catal. 2022, 364, 2479–2501.
24. Xiao Xiao,* Biao Chen, Yi-Ping Yao, Hai-Jie Zhou, Xu Wang, Neng-Zhong Wang, Fen-Er Chen* Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis. Molecules 2022, 27, 6583.
25. Yangxing Sun, Yanzhi Li, Yanlai Cao, Nengzhong Wang, Shaohua Xiang,* Mingguo Liu*, Hui Yao Research Advances in Functional Group-Directed Stereoselective Glycosylation. Chin. J. Org. Chem. 2022, 42, 3506–3529.
26. Mingyue Wu, Zhaobin Han, Huanzhen Ni, Nengzhong Wang, Kuiling Ding,* and Yixin Lu* Phosphine-Catalyzed Divergent Domino Processes Between γ-Substituted Allenoates and Carbonyl-Activated Alkenes. Chem. Sci. 2022, 13, 3161–3168.
27. Nengzhong Wang, Zugen Wu, Junjie Wang, Nisar Ullah,* and Yixin Lu* Recent Applications of Asymmetric Organocatalytic Annulation Reactions in Natural Product Synthesis. Chem. Soc. Rev. 2021, 50, 9766–9793.
28. Nengzhong Wang and Xuefeng Jiang* Synthetic Approaches to Tricyclic Aminoketones in the Total Synthesis of Aspidosperma and Kopsia Alkaloids. Chem. Rec. 2021, 21, 295–314.
29. Nengzhong Wang, Puli Saidhareddy, and Xuefeng Jiang* Construction of Sulfur-Containing Moieties in the Total Synthesis of Natural Products. Nat. Prod. Rep. 2020, 37, 246–275.
30. Nengzhong Wang, Jianrong Liu, Chen Wang, Leiyang Bai, and Xuefeng Jiang* Asymmetric Total Syntheses of (–)-Jerantinines A, C, and E, (–)-16-Methoxytabersonine, (–)-Vindoline and (+)-Vinblastine. Org. Lett. 2018, 20, 292–295.
31. Nengzhong Wang, Shuo Du, Dong Li, and Xuefeng Jiang* Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (–)-Quebrachamine, (+)-Aspidospermidine, (–)-Aspido- spermine, (–)-Pyrifolidine, and Related Natural Products. Org. Lett. 2017, 19, 3167–3170.
32. Minghao Feng, Bingqing Tang, Nengzhong Wang, Hong-Xi Xu, and Xuefeng Jiang* Ligand Controlled Regiodivergent C-1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids, Angew. Chem. Int. Ed. 2015, 54, 14960–14964.
LIST OF GRANTS
1. Natural Science Foundation of Hubei Province of China (2022CFB838).
2. Educational Commission of Hubei Province of China (Q20221212).
3. Natural Science Research Project of Yichang City of China (A23-2-002).
4. Start-up Funding for High-Level Talents of China Three Gorges University (8220309)
