Hui YAO (姚辉)
Professor in Chemistry and Pharmacy, 100 Talent Plan of Hubei Province
Room S3605, College of Biological and Pharmaceutical Sciences,
China Three Gorges University, Yichang 443002, P. R. China.
E-mail: yaohui@ctgu.edu.cn
Education
Aug. 2014-Nov. 2018 Ph.D., Chemistry and Biological Chemistry,
Nanyang Technological University, Singapore
Sept. 2009-Jun. 2012 M.Sc., Medicinal Chemistry
Jinan University, Guangzhou, China
Sept. 2005-Jun. 2009 B.Sc., Pharmacy
Jinan University, Guangzhou, China
Professional Experiences
Oct. 2020 now Hubei Province Distinguished Professor
Jan. 2019 - now University Appointed Professor, China Three Gorges University
Oct. 2018 - Dec. 2018 Research Fellow, Nanyang Technological University, Singapore
Aug. 2012 - Jun. 2014 Research Assistant, The Chinese University of Hong Kong
Research Interests
Carbohydrate chemistry and medicinal chemistry
Publications
1. Yangxing Sun,‡ Keke Ren,‡ Zhentao Zhang, Yanzhi Li, Nengzhong Wang, Hui Zeng, Nianyu Huang,* Xiao-Xi Li,* Wei-Qiao Deng, Hui Yao*, Palladium-Catalyzed O-Glycosylation through π–π Interactions, Org. Lett. 2024, 26, 5396–5401. (JCR Q1, Top, Nature Index)
2. Rui Xie,‡ Jing Xu,‡ Haolin Shi, Chenyu Xiao, Nengzhong Wang,* Nianyu Huang,* Hui Yao,* Stereocontrolled Synthesis of Aryl C-Nucleosides under Ambient Conditions, Org. Lett. 2024, 26, 5162–5166. (JCR Q1, Top, Nature Index)
3. Mingyu Hou, Yiming Xiang, Jingyu Gao, Jingyu Zhang, Nengzhong Wang,* Haolin Shi, Nianyu Huang,* Hui Yao,* Stereoselective Synthesis of 2‑Deoxy Glycosides via Iron Catalysis. Org. Lett. 2023, 25, 832−837. (JCR Q1, Nature Index)
4. Yufei Zhang, Jing Chen, Hui Yao,* Yuanbin Wang, Hongyu Liu, Long Wang, Nianyu Huang,* Nengzhong Wang*. Phosphine-Catalyzed Divergent γ,γ- and ε,γ-Umpolung Domino Additions of Bisoxindoles with Allenoates: Construction of Vicinal All-Carbon Quaternary Stereocenters and Formal Total Synthesis of Dimeric Cyclotryptamine Alkaloids. Chin. J. Chem. 2025, 43, 995–1000. (JCR Q2, Top)
5. Gang Chen,‡ Guangjie Nie,‡ Linxuan Li,* Jie Fu, Hui Yao, Nianyu Huang,* Nengzhong Wang*. Atom-Controlled Divergent Synthesis of Spiro and Fused Rings via Base-Catalyzed Chemoselective Annulation. Org. Chem. Front. 2025, 12, DOI: 10.1039/D4QO02400A. (JCR Q1)
6. Boning Li,‡ Xianfei Hu,‡ Hui Yao,* Yi Li, Dan Xu, Nianyu Huang,* Nengzhong Wang*, Pyridine-Catalyzed Chemoselective Four-Component Cascade Reaction of Aromatic Aldehydes, Malononitrile/Cyanoacetates, MBH Carbonates and Alcohols, Org. Lett. 2024, 26, 7576–7583. (JCR Q1, Top, Nature Index)
7. Shuhui Li,‡ Dan Xu,‡ Hui Yao,* Mengting Tan, Xiaoxuan Li, Mingguo Liu, Long Wang, Nianyu Huang,* and Nengzhong Wang*, Facile Synthesis of 2-Vinylindolines via a Phosphine-Mediated α-Umpolung/Wittig Olefination/Cyclization Cascade Process, Chem. Commun. 2024, 60, 6773-6776. (JCR Q2, Nature Index)
8. Mengting Tan,‡ Yunping Zheng,‡ Sen Zhang, Hui Yao,* Xin Yan, Xing Zhao, Mingguo Liu, Nianyu Huang,* and Nengzhong Wang,* Base-Controlled Chemodivergent [4 + 1] and [2 + 1]/[4 + 2] Annulations of o‑Aminochalcones with γ-Bromocrotonates, Org. Lett. 2024, 26, 9203–9209. (JCR Q1, Top, Nature Index)
9. Shuhui Li,‡ Xiaoxuan Li,‡ Hui Yao,* Mengting Tan, Dan Xu, Nianyu Huang* Nengzhong Wang* Straight-chain ω-amino-α,β-unsaturated carbonyl compounds: versatile synthons for the synthesis of nitrogen-containing heterocycles via organocatalytic reactions. Org. Chem. Front. 2024, 11, 236−253. (JCR Q1)
10. Zhengyang Chen,‡ Dan Xiong,‡ Nengzhong Wang,* Yufei Zhang, Hui Yao, Jinkun Zhang, Nianyu Huang,* and Kun Zou*, Concise Synthesis of Pyrrolo[3,4-c]quinolines via a P(NMe2)3-Catalyzed [4 + 2] Annulation followed by a Zn/AcOH-Mediated Reduction-Hydroamination-Isomerization, Org. Chem. Front. 2024, 11, 2762−2767. (JCR Q1)
11. Yi Li,‡ Xianfei Hu,‡ Boning Li, Sen Zhang, Hui Yao,* Xiao Xiao, Nianyu Huang,* and Nengzhong Wang*, Controllable Phosphine-Catalyzed Three-Component Domino Reaction of Activated Alkenes with Morita−Baylis−Hillman (MBH) Carbonates: Divergent Synthesis of Densely Functionalized Cyclopentanes and Diquinanes, Org. Lett. 2024, 26, 10651–10657. (JCR Q1, Top, Nature Index)
12. Xiaoxiao Zhao,‡ Zhentao Zhang,‡ Jing Xu, Nengzhong Wang,* Nianyu Huang,* Hui Yao,* Stereoselective Synthesis of O Glycosides with Borate Acceptors, J. Org. Chem. 2023, 88, 11735–11747. (IF: 3.6, JCR Q1)
13. Yanyan Wang,‡ Zhen Cao,‡ Nengzhong Wang,* Mingguo Liu, Haifeng Zhou, Long Wang, Nianyu Huang,* Hui Yao*, Palladium-Catalyzed Stereospecific S-Glycosylation by Allylic Substitution, Adv. Synth. Catal. 2023, 365, 1699–1704. (IF: 5.4, JCR Q1)
14. Jingyu Gao,‡ Yi Li,‡ Nengzhong Wang,* Zhiyue Li, Nianyu Huang,* Hui Yao*, One-Pot Stereoselective Synthesis of 2,3,4-Unprotected β-N-Glycopyranosides from Glycals and Amines, Adv. Synth. Catal. 2023, 365, 2350–2355. (IF: 5.4, JCR Q1)（highlighted by Synfacts）
15. Jingrui Wang,‡ Yongkui Feng,‡ Nengzhong Wang, Nianyu Huang,* Hui Yao*, Pd-Catalyzed Stereoselective Synthesis of Nitroalkyl β-C-Glycosides, Chinese Journal of Organic Chemistry, 2023, 43, 3216–3225. (IF: 1.65)
16. Zou Fakai, Wang Nengzhong, Yao Hui*, Wang Hui, Liu Mingguo, Huang Nianyu*. Regio- and Stereo-selective Synthesis of 1β-/3R-Aryl Thiosugar. Chinese Journal of Organic Chemistry, 2024, 44, 593-604. (IF: 1.65)
17. Qiuyuan Wang,‡ Mengnan Lai,‡ Huajun Luo, Keke Ren, Jingrui Wang, Nianyu Huang,* Zhangshuang Deng, Kun Zou,* and Hui Yao*, Stereoselective O-Glycosylation of Glycals with Arylboronic Acids Using Air as the Oxygen Source, Org. Lett. 2022, 24, 1587–1592. (IF: 6.072, JCR Q1, Nature Index, Front Cover)
18. Zhiqiang Lu,* Yanzhi Li, Yi Ru, Shujian Yang, Chu Hao, Mengke Zuo, Rongkai Jiao, Weilong Wu, Yan Zhou, Hui Yao,* Nianyu Huang,* Yuqin Fu*, Coordination Effect Enabled Palladium-Catalyzed Regioselective O-Alkylation of 2-Pyridones, Chem. Commun. 2022, 58, 1215–1218. (IF: 6.065, JCR Q1, Nature Index).
19. Wei-Yi Ding,‡ Huan-Huan Liu,‡ Jun Kee Cheng, Hui Yao,* Shao-Hua Xiang,* Bin Tan, Palladium catalyzed decarboxylative β-C-glycosylation of glycals with oxazol-5-(4H)-ones as acceptors, Org. Chem. Front., 2022, 9, 6149-6155. (IF: 5.456, JCR Q1).
20. Nengzhong Wang,* Xiao Xiao, Cheng-Xiong Liu, Hui Yao,* Nianyu Huang, Kun Zou,* Recent Advances in the Total Synthesis of Aspidosperma and Kopsia Alkaloids Using Tetracyclic Pyridocarbazoles as Versatile Building Blocks, Adv. Synth. Catal. 2022, 364, 2479–2501. (IF: 5.981, JCR Q1).
21. Yuexin Liu,# Yang Jiao,# Huajun Luo, Nianyu Huang,* Mengnan Lai, Kun Zou,* Hui Yao,* Catalyst-Controlled Regiodivergent Synthesis of 1- and 3-Thiosugars with High Stereoselectivity and Chemoselectivity, ACS Catal. 2021, 11, 5287–5293. (IF: 13.7, JCR Q1)
22. Wei-Lin Leng,# Hui Yao,# Jing-Xi He,# and Xue-Wei Liu*, Venturing beyond Donor-Controlled Glycosylation: New Perspectives toward Anomeric Selectivity, Acc. Chem. Res. 2018, 51, 628–639. (Co-first author, IF: 24.466, JCR Q1)
23. Hui Yao, Shasha Zhang, Wei-Lin Leng, Min-Li Leow, Shaohua Xiang, Jingxi He, Hongze Liao, Kim Le Mai Hoang, Xue-Wei Liu*, Catalyst-Controlled Stereoselective O-Glycosylation: Pd(0) vs Pd(II), ACS Catal. 2017, 7, 5456–5460. (IF: 13.7, JCR Q1)
24. Mengnan Lai, Karwan Abdulmajed Othman, Hui Yao,* Qiuyuan Wang, Yongkui Feng, Nianyu Huang,* Mingguo Liu, Kun Zou,* Open-Air Stereoselective Construction of C-Aryl Glycosides, Org. Lett. 2020, 22, 1144–1148. (IF: 6.072, JCR Q1, Nature Index)
25. Ying Wang,# Hui Yao,#,* Min Hua, Yang Jiao, Haibo He, Ming-Guo Liu, Nianyu Huang,* Kun Zou*, Direct N-Glycosylation of Amides/Amines with Glycal Donors, J. Org. Chem. 2020, 85, 7485-7493. (IF: 4.198, JCR Q1)
26. Min Hua, Yangxing Sun, Xueqing Zhang, Hui Yao,* Nianyu Huang,* Convenient Cobalt-catalyzed Stereoselective Synthesis of β-D-thioglucosides, Chin. J. Org. Chem., 2022, 42, 2140-2154. (IF: 1.65)
27. Mengnan Lai, Qiuyuan Wang, Min Hua, Nianyu Huang,* Hui Yao*, Open-Air Stereoselective Synthesis of C-Aryl Fucosides/Arabinosides, Chin. J. Org. Chem. 2022, 42, 1694-1705. (IF: 1.65)
28. Tao Xiong, Rui Xie, Cai Huang, Xin Lan, Nianyu Huang,* Hui Yao*, Recent advances in the synthesis of thiosugars using glycal donors, J. Carbohydr. Chem. 2022, 40, 401-439. (IF: 1.667)
29. Yangxing Sun, Yanzhi Li, Yanlai Cao, Nengzhong Wang, Shaohua Xiang, Mingguo Liu,* Hui Yao, Research Advances in Functional Group-Directed Stereoselective Glycosylation, Chin. J. Org. Chem. 2022, 42, 3506-3529.
30. Yongkui Feng, Hualan Su, Rui Xie, Billy Joel Muuula Otukol, Xueqing Zhang, Hui Yao,* Nianyu Huang,* Synthesis and Crystal Structure of tert-Butyl(((2R,3R,6R)-3-hydroxy-6-(nitromethyl)-3,6-dihydro-2H-pyran-2-yl)methyl)carbonate Chinese J. Struc. Chem. 2021, 40, 1205-1212. (IF: 0.847)
31. Karwan Abdulmajed Othman, Jinjin Cai, Rui Xie, Xinran Zhou, Hui Yao,* Nianyu Huang,* Synthesis and Absolute Configuration of(2R,3S,4Z,6Z)-1,3-bis(benzyloxy)-8-chloro-7-((E)-(2-(2, 4-dinitro-phenyl)hydrazono)methyl)octa-4,6-dien-2-ol, Chinese J. Struc. Chem. 2020, 39, 1781-1787. (IF: 0.847)
32. Hui Yao,# Ronny Willam,# Siming Wang, Tai Guo, Xue-Wei Liu, One-Pot Cascade Transformation of Glycal into Structurally Diverse Drug-Like Scaffolds, Chem. Asian J. 2019, 14, 4024-4030. (IF: 4.839, JCR Q2)
33. Hui Yao,# Minh Duy Vu,# Xue-Wei Liu*, Recent advances in reagent-controlled stereoselective/stereospecific glycosylation, Carbohydr. Res., 2019, 473, 72–81. (IF: 2.975)
34. Xueying You, Yifei Cai, Chenyu Xiao, Lijuan Ma, Yong Wei, Tianpeng Xie, Lei Chen* and Hui Yao,* Stereoselective Synthesis of 2-Deoxythiosugars from Glycals, Molecules, 2022, 27, 7979. (IF: 4.927, JCR 2)
35. Yu Ji, Hui Yao, Yi Liu, Nianyu Huang*, Mingguo Liu*, Synthesis and Cytotoxic Activity of C-Vinyl-rhamnopyranoside Derivatives, Chin. J. Org. Chem., 2020, 40, 2051-2061. (IF: 1.65)
36. Yang Jiao, Jiading Zhang, Shuzhang Wang, Hui Yao, Mingguo Liu,* Niangyu Huang,* Synthesis and Absolute Configuration of ((2R,3R,6S)-3-Hydroxy-6-(naphthalen-2-ylthio)-3,6-dihydro-2H-pyran-2-yl)
methyl Pivalate, Chinese J. Struc. Chem. 2021, 40, 1238-1245. (IF: 0.847)
37. Zhiqiang Lu, Yanzhi Li, Yi Ru, Shujian Yang, Chu Hao, Mengke Zuo, Rongkai Jiao, Hui Yao, The Structure and Property of Two Different Metal-Organic Frameworks Based on N/O-Donor Mixed Ligands, Crystals 2021, 11, 1129. (IF: 2.67)
38. Hongze Liao, Jimei Ma, Hui Yao, Xue-Wei Liu*, Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals, Org. Biomol. Chem., 2018, 16, 1791–1806. (IF: 3.89)
39. Nianyu Huang, Hongze Liao, Hui Yao, Tianpeng Xie, Shasha Zhang, Kun Zou, and Xue-Wei Liu*, Diastereoselective Synthesis of C-Vinyl Glycosides via Gold(I)-Catalyzed Tandem 1,3-Acyloxy Migration/Ferrier Rearrangement, Org. Lett., 2018, 20, 16–19. (IF: 6.072)
40. Wei-Lin Leng, Hongze Liao, Hui Yao, Zi-En Ang, Shaohua Xiang, Xue-Wei Liu*, Palladium-Catalyzed Decarboxylative Allylation/Wittig Reaction: Substrate-Controlled Synthesis of C-Vinyl Glycosides, Org. Lett., 2017, 19, 416-419. (IF: 6.072)
41. Hongze Liao, Wei-Lin Leng, Kim Le Mai Hoang, Hui Yao, Jingxi He, Amanda Ying Hui Voo, Xue-Wei Liu*, Asymmetric syntheses of 8-oxabicyclo[3,2,1]octane and 11-oxatricyclo[5.3.1.0]undecane from glycals, Chem. Sci., 2017, 8, 6656-6661. (IF: 9.969)
42. Ming Lang,# Hui Yao,# Pengfei Fu, Wei Cai, Yuqiang Wang, Pei Yu*, An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system. Res. Chem. Intermed. 2015, 41,5621–5626. (IF: 3.134)
Patents
1. Yuqiang Wang, Hui Yao, Chuanbin Wu, Liang Tao, Yewei Sun, Pengfei Fu, Chloroxime compound, its preparation method and application in pharmacy, CN103804309(A), ZL 201210447383.8.
2. Ho Sup Yoon, Sreekanth Rajan, Hui Ting Toh, Xuewei Liu, Hui Yao, Co-Crystals of Nurr1-LBD In Complex With A Cyclopentenone Prostaglandin And Modulators Of Nurr1, PCT Application No. PCT/SG2017/050476 based on Singapore Patent Application No. 10201607854Q.
Book chapter
1. Wei-Lin Leng,# Jing-Xi He,# Hui Yao,# Xue-Wei Liu, CHAPTER 2 Methodologies in Chemical Syntheses of Carbohydrates. In Synthetic Glycomes, The Royal Society of Chemistry: 2019; pp 15-45. (co-first author)
