导师简介

Email

liuhanghang@ctgu.edu.cn

Admission Major

Chemistry; Pharmacy

Research Interests

Nanomedicine; Natural Products Research and Utilization; Disease Diagnosis and Treatment

Biography

Hanghang Liu, female, born in 1992, holds a doctoral degree and serves as a university-employed associate professor. She received her Bachelor of Science degree from Henan Normal University in June 2015 and her Master of Science degree from Soochow University in June 2018. In June 2022, she obtained her Doctor of Medicine degree from the State Key Laboratory of Radiation Medicine and Protection, Soochow University. In July 2022, she was introduced to the College of Biology and Pharmaceutical Sciences, China Three Gorges University (CTGU) through the Young Top Talent Program. Her research focuses on the construction of multifunctional nanomedicines, the design of intelligent targeted nanodrug delivery systems, and the biomedical applications of natural product nanozymes. Over the past five years, she has published more than 30 SCI papers in internationally renowned journals such as Journal of the American Chemical Society (JACS), Advanced Materials (AM), Nano Today, Advanced Functional Materials, Analytical Chemistry, ACS Applied Materials & Interfaces, and Journal of Materials Chemistry B, including two cover papers.

Main academic papers：

1. Wanyue Fu^#; Zhongshi Huang^#; Weiqi Li; Lingling Xu; Miaomiao Yang; Yan Ma; Hanghang Liu*; Haisheng Qian*; Wanni Wang*, Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease. Bioactive Materials. 2025, 46, 118-133. (IF=18.0)

2. Hanghang Liu^#; Menglong Hua^#; Yaobao Han; Li Yang; Zhongshi Huang; Jiabing Ran; Huimin Wang; Feng Ren*; Changying Yang*; Zhen Li*, Hijacking endogenous iron to amplify lysosomal-mitochondrial cascade damage for boosting anti-tumor immunotherapy. Biomaterials 2025, 316, 122983. (IF=12.8)

3. Hanghang Liu^#; Qing Zheng^#; Jiaxin Yuan; Yifan Gao; Tingting Wang; Hao Zhang; Zhen Li*. Modulating SQSTM1/p62-dependent selective autophagy of neurons by activating Nrf2 with multifunctional nanoparticles to eliminate α-synuclein aggregates and boost therapy of Parkinson’s disease. Nano Today 2023, 49: 101770. (IF=18.962)

4. Hanghang Liu; Menglong Hua; Qing Zheng; Yifan Gao; Zhen Li*. Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles. MedComm – Biomaterials and Applications 2023, 2 (2): e47.

5. Hanghang Liu; Yaobao Han; Tingting Wang; Hao Zhang; Qi Xu; Jiaxin Yuan; Zhen Li*. Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles. Journal of the American Chemical Society 2020, 142 (52): 21730-21742. (IF=16.383，封面)

6. Hanghang Liu; Feng Ren; Xingguo Zhou; Changqiu Ma; Tingting Wang; Hao Zhang; Qiao Sun*; Zhen Li*. Ultra-Sensitive Detection and Inhibition of the Metastasis of Breast Cancer Cells to Adjacent Lymph Nodes and Distant Organs by Using Long-Persistent Luminescence Nanoparticles. Analytical Chemistry 2019, 91 (23): 15064-15072. (IF=8.008，封面)

7. Hanghang Liu; Feng Ren; Hao Zhang; Yaobao Han; Huizhu Qin; Jianfeng Zeng; Yong Wang; Qiao Sun*; Zhen Li*; Mingyuan Gao. Oral administration of highly bright Cr³⁺ doped ZnGa₂O₄ nanocrystals for in vivo targeted imaging of orthotopic breast cancer. Journal of Materials Chemistry B 2018, 6 (10): 1508-1518. (IF=7.571)

8. Hanghang Liu^#; Sepehr Talebian^#; Kara L. Vine; Zhen Li*; Javad Foroughi*. Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy. Nano Select 2022, 3 (1): 212-226.

9. Jiaxin Yuan; Hanghang Liu; Hao Zhang; Tingting Wang; Qing Zheng; Zhen Li*. Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease. Advanced Materials 2022, 34 (11): 2108435. (IF=32.086，封面)

10. Qing Zheng; Hanghang Liu; Hao Zhang; Yaobao Han; Jiaxin Yuan; Tingting Wang; Yifan Gao; Zhen Li*. Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease. Advanced Science 2023, 10 (22): 2300758.

11. Bolin Bao; Hanghang Liu; Yaobao Han; Liyao Xu; Wei Xing*; Zhen Li*. Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury. ACS Applied Materials & Interfaces 2023, 15 (13): 16460-16470.

12. Feng Ren; Hanghang Liu; Hao Zhang; Zhilin Jiang; Bing Xia; Cécile Genevois; Tao He; Mathieu Allix; Qiao Sun; Zhen Li*; Mingyuan Gao. Engineering NIR-IIb fluorescence of Er-based lanthanide nanoparticles for through-skull targeted imaging and imaging-guided surgery of orthotopic glioma. Nano Today 2020, 34: 100905. (IF=18.962)

13. Xingguo Zhou; Hanghang Liu; Yanhui Zheng; Yaobao Han; Tingting Wang; Hao Zhang; Qiao Sun; Zhen Li*. Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor. ACS Applied Materials & Interfaces 2020, 12 (4): 4231-4240. (IF=10.383)

14. Changqiu Ma; Hanghang Liu; Feng Ren; Zheng Liu; Qiao Sun; Chongjun Zhao*; Zhen Li*. The Second Near-Infrared Window Persistent Luminescence for Anti-Counterfeiting Application. Crystal growth & design 2020, 20 (3): 1859-1867. (IF=4.01)

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