叶伟,教授,三峡大学博士后合作导师。湖北省“楚天学者”计划人才。累计发表论文70余篇,一作和通讯发表SCI论文30余篇,包括 J. adv. Res、Bioresource Technol.、J. Agric. Food Chem. 等中科院一区论文7篇。申请专利60余项,以第一发明人授权专利20余项。主持国家级项目2项,省级项目10余项,总经费超过1200万元,参与国家级项目3项。从事大健康原料生物制造、秸秆糖和生物医药中间体和医用辅料生物催化、天然产物生物合成及酵母底盘细胞产高附加值化合物的研究,与安琪酵母股份有限公司、宜昌人福药业责任有限公司和湖北美琪健康科技有限公司在生物制造领域展开了深度产学研合作,共同主持重点研发项目2项。解析了沉香特征成分、抗肿瘤活性成分和单端孢霉烯毒素的生物合成途径,挖掘了新颖的DA酶、糖化酶、氧化还原酶并解析了其催化机制。
主持项目:
1.湖北省技术创新计划重点研发项目,2026BBB007,混合糖同步利用底盘细胞生产高值健康原料关键技术研究,2026/06-2028/05,100万元,在研,技术负责人,共同主持。
2.湖北省技术创新计划重点研发项目,2025BCB028,非粮生物质混合糖同步利用生物合成糖化酶制剂的关键技术,2025/08-2027/08,100万元,在研,主持。
3.国家自然科学基金面上项目,32370081, 深海真菌拟茎点霉新型抗肿瘤聚酮类异二聚体lithocarpins的生物合成机制,2024/01-2027/12,50万元,在研,主持。
4.宜昌人福药业有限责任公司,艾考糊精原料药及γ-环糊精药用辅料等三个糊精类产品工艺开发,SDHZ20250124,80万元,在研,主持。
代表作:
[1] Wei Ye , Mengjun Chen, Haotian Huang, Jinling Guo, Yucai Lyu , Huajun Luo, Dongxu Ma, Xin Wang, Xiao Yang, Dachun Gong*. Rational modification of carbonyl reductase from Candida parapsilosis ATCC 7330 to improve the yield of 2-phenethyl ethanol and (4-Chlorophenyl) (pyridin-2-yl) methanol. Journal of Agricultural Food and Chemistry ((IF=6.7, 中科院一区). 2026, 74, 20544−20557.
[2] Wei Ye, Wenkang Ye, Weiyi She, et al. Genetic modifications boost chrexanthomycin yield and neuroprotective potential Journal of advanced Reserach (IF=17.1, 中科院一区). 2026, 84, 203-215.
[3] Wei Ye, Taomei Liu, Yuping Liu, Mengran Li, Shixin Wang, Saini Li, Weimin Zhang*. Enhancing gliotoxins production in deep-sea derived fungus Dichotomocyes cejpii by engineering the biosynthetic pathway, Bioresource Technology (生物技术领域top期刊,IF=11.899), 2023, 377, 128905.
[4] Wei Ye#, Muzi Zhu#, Saini Li#, Yuchan Chen, Taomei Liu, Haohua Li, Hongxin Liu, Weimin Zhang*. The excavation of novel toxin-resistance proteins against trichothecenes toxins in Paramyrothecium roridum. International Journal of Biological Macromolecules, 2021(中科院一区,IF=8.2), 192, 369-378.
[5] Saini Li, Muzi Zhu, Youfei Cen, Wei Ye*, Shicong Jiang, Xiaoyan Feng, Taomei Liu, Liqiong Xu, Hongxin Liu, Weimin Zhang. Role of tri18 gene in Epiroridin E production and toxin resistance mechanisms in Paramyrothecium roridum. International Journal of Biological Macromolecules, 2024(中科院一区,IF=8.2)280,135746.
[6] Wei Ye, Shan Liu, Xinna Yang, Mengran Li, Taomei Liu, Weiyang Zhang, Yuping Liu, Shixin Wang, Hongxin Liu, Weimin Zhang*. The discovery of a novel single-function intermolecular DA enzyme for the biosynthesis of hetero-dimer lithocarpins in Phomopsis lithocarpus. International Journal of Biological Macromolecules, 2024(中科院一区,IF=8.2), 271, 132539.
[7] Wei Ye#, Xin He#, Hongqing Wu, Lei Wang, Weimin Zhang*, Yunfei Fan, Haohua Li, Taomei Liu, Xiaoxia Gao. Identification and characterization of a novel sesquiterpene synthase from Aquilaria sinensis: An important gene for agarwood formation. International Journal of Biological Macromolecules (中科院一区top,IF=8.2). 2018, 108, 884-892.
