主要研究成果
近年来发表SI/EI论文：
1) He Haibo, Li Xiaomei, Li Daojun, Ding Yonghong, Zhang Yongfeng, Xu Haiyan, Feng Minlu, Xiang Changqing, Zhou Jigang, Zhang Jihong, Liu Hongjun, Chen Maohua. Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/FoxO1/ Pgc-1α and Nrf2/antioxidant defense pathways in rats. Pharmacogn Mag, 2018, 14(54): 1-11.
2) Wang Junzhi, Zhang Pan, He Haibo*, Se Xinxin, Sun Wenjun, Chen Beiyan, Zhang Lin, Yan Ximing, Zou Kun. Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrill attenuates inflammatory responses through inhibiting LPS-induced activation of PI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells. Naunyn Schmiedebergs Arch Pharmacol, 2017, 390(8):845-856.
3) Bai Caihong, Yang Xiaojiao, Zou Kun, He Haibo*, Wang Junzhi, Qin Huilin, Yu Xiaoqin , Liu Chengxiong, Zheng Juyan, Cheng Fan, Chen Jianfeng. Antiproliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation. Naunyn Schmiedebergs Arch Pharmacol, 2016, 389(6):573-584.
4) Zhang Qioayin, Wang Junzhi, He Haibo*, Liu Hongbin, Yan Ximing, Zou Kun. Trametenolic acid B reverses multidrug resistance in breast cancer cells through regulating the expression level of P-glycoprotein. Phytother Res, 2014, 28(7):1037-1044.
5) Wei Na, Zhang Changcheng, He Haibo*, Wang Ting, Liu Zhaoqi, Liu Guangyao, Sun Zhiwei, Zhou Zhiyong, Bai Caihong, Yuan Ding. Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. J Pharm Pharmacol, 2014, 66 (11): 1641-1651.
6) Wang Sa, He Haibo*, Xiao Shuzhang, Wang Jun zhi, Bai Caihong, Na Wei, Kun Zou. Comparison between the cardioprotective effects of labeled and unlabeled oleanoic acid with new BOPIM dye on primary neonatal rat cardiomyocytes following hypoxia/reoxgenation injury. Pharmacological Rep, 2014, 66 (4): 677-685.
7) Huang Shaolan, He Haibo*, Zou Kun, Bai Caihong, Xue Yanhong, Wang Junzhi, Chen Jianfeng. Protective effect of tomatine against hydrogen peroxide-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells. J Pharm Pharmacol, 2014, 66 (4): 844-854.
8) Yuan Ding, Wang Hongwu, He Haibo*, Jia Liangliang, He Yumin, Wang Ting, Zeng Xiao, Li Yuzhou, Li Shouchao, Zhang Changcheng. Protective Effects of total Flavonoids from Epimedium on the male mouse reproductive system against cyclophosphamide-induced oxidative injury by up-regulating the expressions of SOD3 and GPX1. Phytother Res, 2014, 28 (1): 88-97.
9) Jin Guilan, Qin Huilin, He Haibo*, Cheng Fan, Gong Dachun, Xu Bang, Jia Liangliang, Xi Wei, Wang Hongwu, Xiang Xiangfei. Neuroprotective effects of breviscapine against oxidative-stress- Induced cell death in PC12 cells: Involvement of Nrf2/HO-1 pathway. Medicine Sciences and Bioengineering, 2014, 277-282.
10)Bai Caihong, He Haibo*, Cheng Fan, Zou Kun, Wang Junzhi, Liu Guangyao, Deng Wei, Chen Zhifeng, Chen Xiao, Chen Jianfeng. A steroidal saponin RCE-4 inhibits lipopolysaccharide-stimulated inflammatory responses via blocking PI3K/Akt-mediated NF-κB activation in RAW264.7 cells. Applied Mechanics and Materials, 2014, 568-570: 1901-1906.
11)Wei Na, Yuan Ding, He Haibo*, Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponins from Panax japonicas reduces myocardial infarction induced Reactive Oxygen Species production and cardiomyocyte apoptosis via activation of the Nrf-2 pathway. Advanced Materials Research, 2014, 881-883: 339-346.
12)Bai Caihong, He Haibo*, Cheng Fan, Wang Junzhi, Chen Xiao, Zou Kun, Liu Guangyao, Chen Zhifeng, Chen Jianfeng. Cardioprotective effects of saponins from Rhizoma Panacis Majoris on myocardial ischemia/reperfusion injury via scavenging excessive reactive oxygen species. Advanced Materials Research, 2014, 165-172: 165-172.
13)Zhang Jihong, Shi Mengqiong, He Haibo*, Bai Caihong, Wang Junzhi, Cheng Fan, Liu Guangyao, Deng Wei, Zou Kun, Chen Zhifeng. Hepatoprotective effects of saponins from Rhizoma Panacis Majoris on hepatic fibrosis induced by carbon tetrachloride in rats. Applied Mechanics and Materials, 2014, 568-570, 1915-1920.
14)Wei Na, Yuan Ding, He Haibo*, Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponins from Panax japonicas reduces myocardial infarction induced Reactive Oxygen Species production and cardiomyocyte apoptosis via activation of the Nrf-2 pathway. Advanced Materials Research, 2013, 784-789: 367-371.
15)Deng gaigai, Wang junzhi, Zhang Qiaoyin, He Haibo*, Wu Fangfang, Feng Tianyan, Zhou Jigang, Zou Kun, Masao Hattoric. Hepatoprotective effects of Phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats. Biol. Pharm. Bull, 2012, 35(7):1118-112.
16)Huilin Qin, Yongfeng Zhang, Haibo He*, Junzhi Wang, Huajun Luo. Total triterpene from haenomeles speciosa (sweet) Nakaion attenuates the adjuvant induced arthritis by regulating MAPK/NF-κB pathway and pro-inflammatory cytokine in rats. (submitted to J Ethnopharmacol).
17)Haibo He, Huilin Qin, Yongfeng Zhang, Xiaomei LI, Xiaoqin Li, Weihong Yan, Yuling Li. Protective effects of total triterpene from Chaenomeles speciosa (Sweet) Nakai against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. (submitted to J Pharm Pharmacol).
已申请专利和专著：
1. 贺海波, 邹坤, 杨小姣, 刘呈雄, 白彩虹, 王倩, 汪鋆植, 郭志勇, 薛艳红, 杨进. 载体皂苷RCE-4在制备预防或治疗肿瘤的药物中的用途, 2015, 中国, 专利号: ZL201510398812.0.
2. 张继红, 贺海波, 刘雄, 周继刚, 石孟琼, 罗涛, 段砚方, 李玉倩, 蔡燕, 覃慧林, 珠子参皂苷诱导干细胞分化肝细胞及治疗肝病药物的应用. 2015，中国，申请号: CN201510366605.7.
3. 贺海波, 张永峰, 石孟琼, 汪鋆植, 覃慧林, 刘呈雄, 张继红. 木瓜总三萜及其组分在制药中的应用, 2015, 中国, 申请号：CN 201510661042.4.
4. 贺海波, 覃慧林, 石孟琼, 张永峰, 刘呈雄, 汪鋆植, 张继红, 一种皱皮木瓜提取物，提取方法及其应用, 2015, 申请号：CN 201510660595.8.
5. 贺海波, 邹坤, 石孟琼, 汪鋆植, 覃慧林, 刘光耀, 梅志刚, 程凡, 柳蔚, 文宏桥. 一种含鱼腥草叶的复合保健茶及其应用, 2014, 中国, 申请号: CN201410748468.9.
6. 易国之, 卢训丛, 贺海波, 陈涛. 芦荟种植新技术[M], 湖北: 湖北科学技术出版社, 2011.
7. 贺海波, 宋先仁, 石孟琼, 冯芹, 汪鋆植.《肿瘤科中医特效药膳精粹》，华中科技大学出版社，127千字，2015.
近年来获得的科研奖励：
1. 贺海波(2/13), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用.中华中医药学会, 科学技术奖, 三等奖, 2016.
2. 贺海波(2/7), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用, 湖北省人民政府, 湖北省科技进步奖, 三等奖, 2016.
3. 贺海波(2/15), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用，宜昌市人民政府, 宜昌市科技进步奖, 一等奖, 2014.
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